Selected Research and Reviews

Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens

Mark Noviski, Corey Tan, John Huizar, Vivasvan Vykunta, James L. Mueller and Julie Zikherman

J Immunol June 5, 2019, ji1900175; DOI: https://doi.org/10.4049/jimmunol.1900175

 

Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.

Tan C, Mueller JL, Noviski M, Huizar J, Lau D, Dubinin A, Molofsky A, Wilson PC, Zikherman J.

J Immunol. 2019 Apr 8. pii: ji1801565. doi: 10.4049/jimmunol.1801565. [Epub ahead of print] PMID:30962292

 

Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance.

Noviski M, Zikherman J.

Curr Opin Immunol. 2018 Dec;55:67-74. doi: 10.1016/j.coi.2018.09.015. PMID: 30292928

 

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J.

Elife. 2018 Mar 9;7. pii: e35074. doi: 10.7554/eLife.35074.  PMID: 29521626

 

Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells

Huizar J, Tan C, Noviski M, Mueller JL, Zikherman J.
 

Myers DR, Zikherman J, Roose JP.

Trends Immunol. 2017 Jul 25. pii: S1471-4906(17)30125-4. doi: 10.1016/j.it.2017.06.010. [Epub ahead of print] Review. PMID:28754596

 
 

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.

Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J.

J Immunol. 2017 Mar 15;198(6):2445-2456. doi: 10.4049/jimmunol.1601453. PMID:28159902

 

An extracatalytic function of CD45 in B cells is mediated by CD22.

Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6515-24. doi: 10.1073/pnas.1519925112. PMID:26561584

 

Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.

Mueller J, Matloubian M, Zikherman J.

J Immunol. 2015 Apr 1;194(7):2993-7. doi: 10.4049/jimmunol.1403086. PMID:25725108

 

The role of T cell receptor signaling thresholds in guiding T cell fate decisions.

Zikherman J, Au-Yeung B.

Curr Opin Immunol. 2015 Apr;33:43-8. doi: 10.1016/j.coi.2015.01.012. Epub 2015 Feb 6. Review. PMID: 25660212

 

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.

Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88. doi: 10.1073/pnas.1413726111. Epub 2014 Aug 18. PMID: 25136127

 

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Zikherman J, Parameswaran R, Hermiston M, Weiss A.

J Immunol. 2013 Mar 15;190(6):2527-35. doi: 10.4049/jimmunol.1202928. Epub 2013 Feb 8. PMID: 23396948

 

Endogenous antigen tunes the responsiveness of naive B cells but not T cells.

Zikherman J, Parameswaran R, Weiss A.

Nature. 2012 Sep 6;489(7414):160-4. doi: 10.1038/nature11311. PMID: 22902503

 

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.

Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):E3-12. doi: 10.1073/pnas.1117374108. Epub 2011 Nov 30. PMID: 22135465

 

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.

Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A.

Immunity. 2010 Mar 26;32(3):342-54. doi: 10.1016/j.immuni.2010.03.006. PMID: 20346773

Complete List of Publications