Selected Research and Reviews

Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens

Mark Noviski, Corey Tan, John Huizar, Vivasvan Vykunta, James L. Mueller and Julie Zikherman

J Immunol June 5, 2019, ji1900175; DOI: https://doi.org/10.4049/jimmunol.1900175

 

Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.

Tan C, Mueller JL, Noviski M, Huizar J, Lau D, Dubinin A, Molofsky A, Wilson PC, Zikherman J.

J Immunol. 2019 Apr 8. pii: ji1801565. doi: 10.4049/jimmunol.1801565. [Epub ahead of print] PMID:30962292

 

Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance.

Noviski M, Zikherman J.

Curr Opin Immunol. 2018 Dec;55:67-74. doi: 10.1016/j.coi.2018.09.015. PMID: 30292928

 

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J.

Elife. 2018 Mar 9;7. pii: e35074. doi: 10.7554/eLife.35074.  PMID: 29521626

 

Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells

Huizar J, Tan C, Noviski M, Mueller JL, Zikherman J.
 
ImmunoHorizons. November 1, 2017, 1 (9) 188-197; DOI: https://doi.org/10.4049/immunohorizons.1700048. PMID: 29152611
 
 
 

B cell autoimmunity at the extremes.

Zikherman J, Lowell CA.

Nat Immunol. 2017 Sep 19;18(10):1065-1066. doi: 10.1038/ni.3840. PMID: 28926534

 
 

Tonic Signals: Why Do Lymphocytes Bother?

Myers DR, Zikherman J, Roose JP.

Trends Immunol. 2017 Jul 25. pii: S1471-4906(17)30125-4. doi: 10.1016/j.it.2017.06.010. [Epub ahead of print] Review. PMID:28754596

 
 

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.

Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J.

J Immunol. 2017 Mar 15;198(6):2445-2456. doi: 10.4049/jimmunol.1601453. PMID:28159902

 

An extracatalytic function of CD45 in B cells is mediated by CD22.

Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6515-24. doi: 10.1073/pnas.1519925112. PMID:26561584

 

Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.

Mueller J, Matloubian M, Zikherman J.

J Immunol. 2015 Apr 1;194(7):2993-7. doi: 10.4049/jimmunol.1403086. PMID:25725108

 

The role of T cell receptor signaling thresholds in guiding T cell fate decisions.

Zikherman J, Au-Yeung B.

Curr Opin Immunol. 2015 Apr;33:43-8. doi: 10.1016/j.coi.2015.01.012. Epub 2015 Feb 6. Review. PMID: 25660212

 

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.

Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88. doi: 10.1073/pnas.1413726111. Epub 2014 Aug 18. PMID: 25136127

 

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Zikherman J, Parameswaran R, Hermiston M, Weiss A.

J Immunol. 2013 Mar 15;190(6):2527-35. doi: 10.4049/jimmunol.1202928. Epub 2013 Feb 8. PMID: 23396948

 

Endogenous antigen tunes the responsiveness of naive B cells but not T cells.

Zikherman J, Parameswaran R, Weiss A.

Nature. 2012 Sep 6;489(7414):160-4. doi: 10.1038/nature11311. PMID: 22902503

 

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.

Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):E3-12. doi: 10.1073/pnas.1117374108. Epub 2011 Nov 30. PMID: 22135465

 

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.

Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A.

Immunity. 2010 Mar 26;32(3):342-54. doi: 10.1016/j.immuni.2010.03.006. PMID: 20346773

Complete List of Publications