Selected Research and Reviews
Molecular basis for potent B cell responses to antigen displayed on particles of viral size
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance.
Hiwa R, Brooks JF, Mueller JL, Nielsen HV, Zikherman J.
Immunological Reviews. 2022 Feb 17. doi: 10.1111/imr.13072. PMID: 35174510
Ryosuke Hiwa, Hailyn V. Nielsen, James L. Mueller, Ravi Mandla, and Julie Zikherman.
JCI Insight 2021 Sep 8;6(17):151005. doi: 10.1172/jci.insight.151005. PMID: 34343134
Jeremy F Brooks, Corey Tan, James L. Mueller, Kenta Hibiya, Ryosuke Hiwa, Julie Zikherman.
Cell Reports 2021 Aug 31;36(9):109645. doi: 10.1016/j.celrep.2021.109645. PMID: 34469720
ATP-competitive partial antagonists of IRE-1α’s RNase segregate outputs of the UPR
Hannah C. Feldman, Rajarshi Ghosh, Vincent C. Auyeung, James L. Mueller, Jae-Hong Kim, Zachary E. Potter, Venkata N. Vidadala, B. Gayani K. Perera,
Alina Olivier, Bradley J. Backes, Julie Zikherman, Feroz R. Papa, Dustin J. Maly
Nature Chemical Biology 2021 Sep 23. doi: 10.1038/s41589-021-00852-0. PMID: 34556859
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting
Tan C, Hiwa R, Mueller JL, Vykunta V, Hibiya K, Noviski M, Huizar J, Brooks JF, Garcia J, Heyn C, Li Z, Marson A, Zikherman J.
Nature Immunology. 2020 Oct;21(10):1267-1279. doi: 10.1038/s41590-020-0765-7. PMID: 32868928
Synthetic Liposomal Mimics of Biological Viruses for the Study of Immune Responses to Infection and Vaccination
Wei-Yun Wholey, James L. Mueller, Corey Tan, Jeremy F. Brooks, Julie Zikherman, Wei Cheng
Bioconjug Chem. 2020 Jan 23. doi: 10.1021/acs.bioconjchem.9b00825. PMID: 31940172
Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens
Mark Noviski, Corey Tan, John Huizar, Vivasvan Vykunta, James L. Mueller and Julie Zikherman
J Immunol June 5, 2019, ji1900175; DOI: https://doi.org/10.4049/jimmunol.1900175. PMID: 31167773
Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.
Tan C, Mueller JL, Noviski M, Huizar J, Lau D, Dubinin A, Molofsky A, Wilson PC, Zikherman J.
J Immunol. 2019 Apr 8. pii: ji1801565. doi: 10.4049/jimmunol.1801565. PMID:30962292
IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J.
Elife. 2018 Mar 9;7. pii: e35074. doi: 10.7554/eLife.35074. PMID: 29521626
Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells
Huizar J, Tan C, Noviski M, Mueller JL, Zikherman J.
ImmunoHorizons. November 1, 2017, 1 (9) 188-197; DOI: https://doi.org/10.4049/immunohorizons.1700048. PMID: 29152611
IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.
Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J.
J Immunol. 2017 Mar 15;198(6):2445-2456. doi: 10.4049/jimmunol.1601453. PMID:28159902
An extracatalytic function of CD45 in B cells is mediated by CD22.
Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J.
Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6515-24. doi: 10.1073/pnas.1519925112. PMID:26561584
Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.
Mueller J, Matloubian M, Zikherman J.
J Immunol. 2015 Apr 1;194(7):2993-7. doi: 10.4049/jimmunol.1403086. PMID:25725108
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A.
Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88. doi: 10.1073/pnas.1413726111.
Endogenous antigen tunes the responsiveness of naive B cells but not T cells.
Zikherman J, Parameswaran R, Weiss A.
Nature. 2012 Sep 6;489(7414):160-4. doi: 10.1038/nature11311. PMID: 22902503
Complete List of Publications